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When an air raid siren sounds in Israel, people know what to do - get to the nearest shelter. 

Families and foreign workers have carried mattresses, sleeping bags and snacks into an old nuclear shleter in Tel Aviv several times a day. 

Since 13 June, Israel has launched airstrikes targeting Iranian nuclear and military sites as well as top generals and nuclear scientists.

Iran has retaliated by firing 450 missiles and more than 1,000 drones at Israel, according to Israeli army estimates.

Missiles have struck 40 different sites, including apartment buildings, offices and a hospital, according to authorities.

Two centrifuge production sites have been struck in Iran, an Israeli military official has said. 

Reuters reported that the unnamed official said the sites were in Isfahan, a central city that is home to one of Iran's biggest nuclear facilities. 

Earlier today, Iran's Fars news agency said the Isfahan nuclear facility had been targeted by an Israeli attack. 

Centrifuges are used to enrich uranium, which can be used for domestic purposes but also for nuclear weapons. 

Russia has repeatedly told Israel that Iran has no intentions of obtaining nuclear weapons, Vladimir Putin has said. 

Speaking to Sky News Arabia, Putin said: "I must say that Russia, like the IAEA [International Atomic Energy Agency], has no evidence that Iran is preparing to acquire nuclear weapons."

"If Israel has any concerns, then they need to be addressed, and there are forms and possibilities for addressing these concerns, as I have already said, in my opinion," the Russian president added. 

It comes after US President Donald Trump said his intelligence agencies were wrong in suggesting there was no evidence Iran is building a nuclear weapon.

Israel has justified its airstrikes on Iranian nuclear and military targets by saying Tehran was on the verge of having a warhead.

Iran has denied developing nuclear weapons, saying its uranium enrichment programme is only for peaceful purposes.

But it is the only non-nuclear-weapon state to enrich uranium up to 60% - which is close to weapons-grade levels of 90%. 

You can read more about this in our 7.45 post. 

Five members of Iran's Revolutionary Guard Corps have been killed in an Israeli attack, the force has told Iranian state media. 

This elite military unit is the dominant branch of the Iranian armed forces.

It was set up shortly after the 1979 Islamic Revolution, when a movement led by Muslim students led to the overthrowing of the US-backed Pahlavi dynasty.

It was introduced to provide extra protection for the new regime and to act as a counterweight to the regular armed forces.

It has an estimated 125,000-strong military with army, navy and air units - some analysts believe the figure is far higher.

Last night, Donald Trump said US intelligence agencies were "wrong" after they said they had no evidence that Iran was building a nuclear weapon. 

Iran has repeatedly denied that it is seeking a nuclear weapon and the head of the UN's nuclear watchdog said in June that it has no proof of a "systematic effort to move into a nuclear weapon".

But it is the only non-nuclear-weapon state to enrich uranium up to 60% - a short, technical step away from weapons-grade levels of 90%. 

So, how close is Iran to producing a nuclear weapon? Our US correspondent Mark Stone takes a look...

The situation in the Middle East is "perilous", the UK's foreign secretary has said as he urged Iran to negotiate with the US.

David Lammy flew from Washington to Geneva yesterday to meet Iranian foreign minister Abbas Araghchi alongside his French and German counterparts. 

"It is still clear to me, as President Trump indicated yesterday, that there is a window of within two weeks where we can see a diplomatic solution," he said.

Urging Iran to "take that off ramp" and talk to the Americans, he said: "We have a window of time. This is perilous and deadly serious."

The talks followed US President Donald Trump's announcement that he would delay a decision on joining Israeli strikes against Iran for up to two weeks.

Iran has said it will not negotiate with the US as long as Israel continued to carry out airstrikes against the country. 

A veteran Iranian commander has been killed in a strike, Israel's defence minister has said. 

Israel Katz said the commander was in Iran's Quds Force - the overseas arm of the Iranian Revolutionary Guards. 

He has been identified as Saeed Izadi, who led the Palestine Corps of the Quds Force.

He was killed in a strike in an apartment in Iran's central city Qom, Katz said. 

Iranian news outlets have been reporting that a building in the Iranian city of Qom was attacked in the early hours of this morning.

For context: The Quds Force built up a network of Arab allies known as the Axis of Resistance, establishing Hezbollah in Lebanon in 1982 and supporting the Palestinian militant Islamist group Hamas in Gaza. 

But the network has suffered major blows over the last two years, as Israeli offensives since Hamas' 7 October 2023 attacks on Israel have weakened both the Palestinian group and Hezbollah. 

Iran and Israel have exchanged fresh attacks this morning after Tehran said it would not negotiate over its nuclear programme while under threat. 

Iran's Fars news agency said the Isfahan nuclear facility, one of the country's largest, had been targeted. 

It said the attack had not caused a hazardous waste leak. 

A building in the Iranian city of Qom was also reportedly attacked, with Iranian media saying a 16-year-old boy had been killed. 

The Israeli military said it had launched a wave of attacks against missile storage and launch infrastructure sites in Iran.

At around 2.30am local time, air raid sirens sounded across parts of central Israel as the military warned of an incoming missile barrage from Iran. 

Interceptions were visible in the AG百家乐在线官网 over Tel Aviv, with
explosions echoing across the metropolitan area as Israel鈥檚 air
defence systems responded.

Welcome back to our live coverage of the Israel-Iran conflict. 

Last night, Donald Trump said it was "very hard" to ask Israel to stop its attacks - something Iran has called on the US to do. 

It came after Iran said it would not negotiate over its nuclear programme while under threat. 

Iranian Foreign Minister Abbas Araghchi said there was no room for negotiations with the US "until Israeli aggression stops".

But he arrived in Geneva on Friday for talks with European foreign ministers, who hope to establish a path back to diplomacy. 

Israel's ambassador to the United Nations Danny Danon has vowed his country "will not stop" attacks on Iran until the "nuclear threat is dismantled" and "its war machine is disarmed".

Israel began attacking Iran on 13 June, saying its longtime enemy was on the verge of developing nuclear weapons.

Iran, which says its nuclear programme is only for peaceful purposes, retaliated with missile and drone strikes on Israel.

We'll bring you all the latest updates throughout the day... 

By Ben van der Merwe, Adam Parker, Kaitlin Tosh and Sophia Massam, Data & Forensics Unit

Flight tracking data shows extensive movement of US military aircraft towards the Middle East in recent days, including via the UK.

Fifty-two US military planes were spotted flying over the eastern Mediterranean towards the Middle East between Monday and Thursday.

That includes at least 25 that passed through Chania airport, on the Greek island of Crete - an eight-fold increase in the rate of arrivals compared to the first half of June.