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The daughter of a human rights lawyer held in a prison located in an area targeted by Israeli missile strikes has begged for his release.

Mehraveh Khandan's father, Reza Khandan, has been in Evin prison since December, serving a sentence of four years and one month for charges of "assembly and collusion" and "propaganda against the regime" for producing pins opposing the mandatory wearing of the hijab by women.

The prison is located in Tehran's district 3, which is subject to an evacuation order issued by Israel on Monday due to its military targeting the area with missile and drone strikes.

After Donald Trump said the city should be evacuated "immediately", Mehraveh, 25, shared a tearful video on Instagram, asking: "How can he leave Tehran, he is in prison?"

This is "one of the most helpless and hopeless times of my life", Mehraveh told Sky News.

By Michael Drummond, foreign news reporter

Israel hit more targets in Iran overnight, including multiple nuclear facilities.

The Israeli military said it targeted the Khondab nuclear reactor in Iran's Arak, including its partially built heavy-water research reactor. 

Heavy-water reactors pose a nuclear proliferation risk because they can easily produce plutonium, which can be used as the core of a nuclear bomb.

The IDF said it also struck a site in the area of Natanz, one of Iran's uranium enrichment plants. 

However, despite days of Israeli strikes on infrastructure associated with Iran's nuclear programme, it appears that much of Iran's deeply-buried nuclear apparatus may remain intact.

At Natanz, Israel has been unable to breach the subterranean hall of centrifuges, but damage to its power supply is thought to have caused serious damage to the centrifuges indirectly.

At Fordow, the secretive enrichment plant buried deep beneath a mountain, it's thought that only America's GBU-57, a 14-ton bunker buster bomb is powerful enough to destroy the facility.

It's understood that it can penetrate about 200ft (61m) below the surface before exploding.

But analysts say it can only be delivered from a US B-2 stealth bomber. Its 30,000lb (13,600kg) weight means that its sheer kinetic force enables it to reach deeply buried targets. 

Read on here...

As Karoline Leavitt wraps up her press briefing, questions were dominated by the conflict between Israel and Iran.

The White House press secretary even read out a statement from Donald Trump, in which he said he will make a decision on attacking Iran in the next two weeks (see previous post).

But there were four critical words in the US president's statement, our correspondent David Blevins has said, pointing out that Trump referred to a "substantial chance of negotiations".

"She confirmed that the president's special envoy Steve Witkoff was still in contact with the Iranians, and she talked about the president desiring diplomacy, but being unafraid to take military action if required," he said.

"She talked about the proposal to Iran being reasonable and rational, and said regime change was not the president's priority right now."

Blevins describes it as "quite a telling" press briefing, with confirmation that Trump is leaving perhaps as long as two weeks before he decides on exactly whether or not there will be US military action against Iran.

Former Israeli defence minister Benny Gantz was among those to have met Benjamin Netanyahu for a security briefing today.

Speaking after the meeting, he told our lead world news presenter Yalda Hakim that "there's simply right or wrong" over Iran, insisting "I think we are right".

When asked whether Netanyahu has been reckless, Gantz said: "I don't think that's true.

"We've been waiting more than 18 years with this issue.

"We have tried everything we can think of, and yet Iranians continued to develop their nuclear capabilities and their missile programmes."

Gantz went on to say Iran has "supported all these proxies around us in Syria, Lebanon, Yemen and in Gaza".

"Look at what happened on October 7th, this is all made in Iran."

Watch the full interview in the video below.

White House press secretary Karoline Leavitt is holding a regular news briefing.

After starting off by talking about domestic topics, Leavitt turns to the conflict between Israel and Iran.

"I know there has been a lot of speculation... regarding the president's decision-making and whether or not the US will be involved," she says.

Leavitt then reads out a direct quote from Donald Trump.

"Based on the fact that there's a substantial chance of negotiations that may or may not take place with Iran in the near future, I will make my decision whether or not to go within the next two weeks."

Leavitt says "nobody should be surprised" by Trump's position that Iran absolutely cannot obtain a nuclear weapon, adding that he has been "unequivocally clear about this for decades".

When asked about whether Trump has any expectations ahead of European foreign secretaries meeting their Iranian counterpart tomorrow, Leavitt says "the entire world is on the president's side".

She tells reporters that the message Iran cannot obtain a nuclear weapon "is something pretty much all of humanity, except the Iranian terrorist regime themselves, agree upon".

"The president expects that Europe will deliver that message directly to the Iranians," she adds.

Trump 'unafraid' to use strength if necessary, White House says

Leavitt goes on to describe Iran as being in a "very weak and vulnerable position" due to attacks from Israel, and says Trump has been very direct and clear in his message - Iran "can and should" make a deal.

"I think the president has made it clear he always wants to pursue diplomacy," she says, before insisting that he is "unafraid to use strength if necessary".

"Iran and the entire world should know that the US military is the strongest and most lethal fighting force in the world, and we have capabilities that no other country on this planet possesses," she adds.

While we wait for White House press secretary Karoline Leavitt to speak, we're hearing from our US partner network NBC News that only 65% of the missiles launched by Iran in the last 24 hours were intercepted by the Iron Dome system.

That's down from almost 90% the day before, according to a former top-level Israeli intelligence official, who still receives daily government briefings.

"Iran still has very advanced missiles, and they are making use of them," the official told NBC.

Faster Iranian missiles launched in the last day have given Israel less time to prepare before the projectiles approach their targets, they said.

"Until yesterday, we got an early warning of about 10 to 11 minutes before the missiles actually fell, but this morning, it was six or seven minutes," they said.

"More importantly, the Iranians do have a navigation system for the final phase of the attack that helps them to be very precise and to attack exactly the targets that they wish, like the hospital today in Beer Sheba."

Iran denies it attacked the hospital directly, claiming it was damaged by the shockwave of a strike on a nearby military headquarters.

We're expecting to hear from White House press secretary Karoline Leavitt shortly.

She will be taking questions from reporters, and we'll bring you anything she says on the conflict between Israel and Iran.

You can watch along in the live stream at the top of this page. We'll also be providing text updates here.

Here are some of the latest pictures from the Israel-Iran conflict.

On Monday, Israel carried out a strike on Israeli state broadcaster IRIB which the TV station was broadcasting.

A presenter was live on air when the explosion rocked her studio, causing her to flee off-screen as debris fell.

The pictures below were taken today, and show the aftermath of the attack on the site.

France's ambassador to the United Kingdom has told Sky News that there is no military solution to eliminating Iran's nuclear programme, and called for de-escalation and a return to negotiations.

Speaking to our political editor Beth Rigby, Helene Duchene said France is "very concerned" about Iran's nuclear programme, but argued that negotiation is the path forward rather than the risk of broader regional instability.

"The message we have is that we are, of course, very concerned by the Iranian nuclear programme," she said. 

"It's a serious threat to our security interests, to the security interests of the region. We see that for long since this programme has been discovered in 2003.

"But we don't think that there is a military solution for eliminating this nuclear programme because, you know, even destroying Fordow [an Iranian nuclear facility] would maybe delay, degrade the programme."

Watch the interview in the video below.

US special envoy Steve Witkoff has spoken to Iran's foreign minister several times over the phone since Israel began its strikes on Iran last week, three diplomats have told Reuters.

The talks are part of efforts to find an end to the conflict, and mark the most substantive direct discussions between the US and Iran since they began negotiations in April.

Abbas Araqchi is reported to have told Witkoff that Tehran would not return to negotiations unless Israel stopped its attacks.

The diplomats also said the talks included a brief discussion of a US proposal given to Iran at the end of last month, aiming to create a regional consortium that would enrich uranium outside of Iran - something Tehran has so far rejected.

It comes as UK Foreign Secretary David Lammy will be meeting US secretary of state Marco Rubio in Washington today.

Our US partner network NBC News has been told Witkoff will also be present at that meeting.