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The US dropped 12 bunker buster bombs on the Fordow nuclear facility overnight, according to a US report.

The New York Times has reported that six B-2 bombers dropped 12 bunker buster bombs on the Fordow nuclear site.

Then, US Navy submarines reportedly launched 30 cruise missiles at Natanz and Isfahan - two other crucial nuclear sites.

A B-2 bomber was also said to have dropped two bunker buster bombs on Natanz, the NYT reported, citing an official.

The strikes were said to be the culmination of years of planning.

For context: Since Israel began the latest wave of fighting by striking Iran, it has said its key objective is crippling Iran's nuclear infrastructure.

Now, it's got the US onboard with the goal.

Israel kicked off its attacks by hitting the likes of Fordow, Isfahan and Natanz.

The three sites are key for enriching uranium for Iran's nuclear programme.

However, Fordow is also built into a mountainside, meaning it has remained largely out of reach of Israel's ordnance.

That's partly why US involvement was thought to be so key - its bunker buster bombs were one of the few weapons capable of penetrating deep enough to get to Fordow.

UN chief Antonio Guterres has said he is "gravely alarmed" by the US attacks on Iran.

The secretary general described the attacks on Iran's nuclear infrastructure as a "dangerous escalation".

He added: "There is a growing risk that this conflict could rapidly get out of control 鈥� with catastrophic consequences for civilians, the region, and the world. "

Read his full message below:

I am gravely alarmed by the use of force by the United States against Iran today. This is a dangerous escalation in a region already on the edge 鈥� and a direct threat to international peace and security. There is a growing risk that this conflict could rapidly get out of control 鈥� with catastrophic consequences for civilians, the region, and the world. I call on Member States to de-escalate and to uphold their obligations under the @UN Charter and other rules of international law. At this perilous hour, it is critical to avoid a spiral of chaos. There is no military solution. The only path forward is diplomacy. The only hope is peace.

We've just been hearing from our US correspondent Mark Stone with the latest from the White House.

He explained that Donald Trump has "made it clear that Iran should not retaliate".

"Clearly behind the scenes, he has a good degree of confidence that they won't, because remember, there is a domestic political calculation that he is making here.

"Many around him, and many in his 'make America great again' coalition, are vehemently against America getting in any way involved in what they see as Israel's war, not their war.

"And so, what he's trying to do, and what he hopes he has done with this overnight strike, is one massive game-changing strike which just draws a line under everything."

Stone went on to say that the two aims of the American strike were to stop Iran's nuclear programme "once and for all", and to ensure that Iran's capability to strike back is "diminished to such an extent that they cannot cause a mass casualty event" either in Israel or against American assets.

"Time will tell," he said, but one strike that sees any deaths among the roughly 40,000 American service personnel stationed in the Middle East could see the situation "spiral".

Watch: US strikes on Iran explained

We've just had a statement from the UK prime minister in response to the American strikes against Iranian nuclear sites overnight.

Sir Keir Starmer said: "Iran's nuclear programme is a grave threat to international security. Iran can never be allowed to develop a nuclear weapon, and the US has taken action to alleviate that threat.

"The situation in the Middle East remains volatile and stability in the region is a priority. We call on Iran to return to the negotiating table and reach a diplomatic solution to end this crisis."

Sky News understands that there was no UK involvement in the strikes.

A NATO official has said the alliance is watching the Middle East closely after the US strikes on Iran's nuclear infrastructure overnight.

An official made the comments to the Reuters news agency when asked about the alliance's reaction to the attacks.

"Of course we're watching the situation closely," the official said.

Here are some of the latest images from the Israel-Iran conflict.

In the northern port city of Haifa in Israel, Iranian strikes have destroyed some buildings.

It is one of a number of areas in central and northern parts of the country that were hit by a barrage of Iranian missiles fired this morning.

Iran's response follows US attacks on three nuclear sites overnight.

In the last few minutes, the IDF has announced that the Israeli Air Force has begun a "wave of attacks against military targets in western Iran".

It follows a barrage of missiles from Iran in the wake of the US attack on three nuclear sites.

The IDF says the air force attacked missile launchers in Iran that were targeting Israel, sites where missiles were just launched from, as well as "soldiers in the Iranian military forces".

Iranian missiles have hit Tel Aviv, as Iran's retaliation for the US strikes overnight continues.

Footage on social media shows the impact site in the Israeli city, where the front of a large building has been destroyed.

Emergency responders are at the scene, working among the rubble.

We brought you news earlier that Tel Aviv was among the areas in northern and central Israel that had been hit - see our 6.50 post.

By Alistair Bunkall, Middle East correspondent, in Jerusalem

As the sun rises above Jerusalem this morning, Israelis will be waking to the news that America has joined their war and attacked Iran. It will be met with mixed feelings.

For the first night in over a week, there was no Iranian missile attack on Israel, but while the new day brings comfort in US military support, there will also be deep trepidation that this war has entered a dangerous and potentially uncontrollable phase.

Benjamin Netanyahu released a video statement praising the US president and saying peace comes through strength; Donald Trump addressed the American nation and warned Iran he would not hesitate to order further action if it retaliates.

What happens next is largely in Iran's control. What they choose to do will determine the future of this region.

The question is now not whether they will respond, but how?

Some lines to bring you now from Iran's foreign ministry.

Iran has the right to respond with all its might to military aggression by the US, the ministry says. 

It added that the world must not forget the US struck militarily during a diplomatic process - referencing ongoing talks about Iran's nuclear programme. 

Britain's David Lammy met his Iranian counterpart, along with European foreign ministers, in Geneva this week.