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Our lead world news presenter Yalda Hakim is in Jerusalem where air raid sirens are blaring as Israel faces yet another barrage of missiles from Iran.

"This is what the people here have been having to deal with over the course of the last few days since Israel launched their attack on the Iranian regime," she says.

"I can see people running to their bunkers and rushing to safety."

Missiles have also been seen over Tel Aviv.

People in Tehran have been leaving towards the north of the country in large numbers, the Islamic Republic News Agency (IRNA) reports.

The news agency notes that there is heavy traffic at all road exits from Tehran.

Earlier, new explosions echoed across Tehran and were reported elsewhere in the country.

Israeli strikes targeted Iran's Defence Ministry after hitting air defences, military bases and sites associated with its nuclear programme.

Air raid sirens rang out across Tel Aviv and Jerusalem today as Israel and Iran exchanged missile attacks for a third consecutive day.

It was the first time Iran fired missiles during the day.

Here, our Middle East correspondent Alistair Bunkall reports from Tel Aviv...

Following on from our last post, Benjamin Netanyahu has denied reports that Donald Trump vetoed Israel's request to kill Ayatollah Khamenei. 

In an interview with Fox News' Bret Baier, the Israeli leader said: "There's so many false reports of conversations that never happened, and I'm not going to get into that.

"But I can tell you, I think that we do what we need to do, we'll do what we need to do. And I think the United States knows what is good for the United States."

He also said attacks will end "when we remove" Iran's nuclear capabilities.

Donald Trump vetoed an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, two US officials have told Reuters.

One of the sources said: "Have the Iranians killed an American yet? No. Until they do we're not even talking about going after the political leadership."

Who is Iran's supreme leader?

Iran's supreme leader Ayatollah Ali Khamenei serves as commander-in-chief of the armed forces and controls the Revolutionary Guard.

He has the final say on all major policies in the country.

Scenes from Mashhad Airport in northeast Iran show large plumes of smoke emerging from the ground. 

The IDF has said Israel's air force attacked an Iranian refueling plane at the airport.

"The air force is working to achieve air superiority throughout Iran," the IDF said.

Earlier, footage also showed smoke rising near Iran's Ministry of Justice building in Tehran. 

At least 406 people have been killed by Israeli strikes in Iran, a human rights group has said.

The Washington-based Human Rights Activists also reports that another 654 people have been wounded from the strikes, according to the Associated Press.

The figures cover the entirety of Iran.

The Iranian government has not yet published overall casualty figures.

More images are coming through of emergency crews at the scene of a damaged residential building in Tamra, northern Israel, after Iran's missile strike.

The scenes come as Israel unleashed airstrikes across Iran for a third day and threatened even greater force as some Iranian missiles evaded Israeli air defences to strike buildings in the country.

Footage has emerged of smoke rising near Iran's Ministry of Justice building in Tehran. 

We are still waiting on more information but the scenes come after explosions were reported in Tehran earlier today.

Tasnim news agency reported one blast happened in the Vali-e-Asr Square area in the centre of the city.

Another explosion was heard in the Niroo Havaei neighbourhood, in the east of the city, where the air force headquarters are located.

Another airline has cancelled flights in the region, due to the escalating conflict.

Etihad Airways has cancelled flights between Abu Dhabi and Tel Aviv until June 22, it has said today.

"This remains a developing situation, and some disruption and delays may be expected in the coming days," it said in a statement. 

It follows a raft of other airlines that have cancelled flights.

Israeli airline El Al said it is moving its planes out of Israel in anticipation of Iranian attacks on Ben Gurion airport.

Aegean Airlines said it is suspending all flights to and from Tel Aviv.

Emirates Airlines said certain flights were cancelled "due to the current situation".

Although planes were initially unable to fly over some parts of the Middle East, Syria has joined Jordan and Lebanon in reopening airspace today.